As a species, we have a problem. Bacteria are becoming more and more resistant to antibiotics. Makes sense: Antibiotics kill off all the bacteria they can, but the remaining ones that somehow survive continue to grow and spread. Guess which gene they all have in common? That’s right, the one that makes them resistant to antibiotics.
We’ve known this for years, but instead of accelerating, the work on new antibiotics is slowing down significantly. Why? Capitalism: It’s really expensive to develop new drugs, and once they’re developed, it’s hard to make a lot of money on them.
PhageLab wants to come to the rescue with a different approach: using a phage (short for “bacteriophage”). Phages are a type of virus that infects bacteria and kills them. Unlike traditional antibiotics, phages can be designed to target very specific bacteria, and that lets us use them to kill only the bacteria you don’t want (say, salmonella), while your gut bacteria stay more or less intact.
Of course, the process is not without downsides. One of the reasons broad-spectrum antibiotics work so well is that doctors often don’t know exactly which bacteria are wreaking havoc, and if you have a phage that attacks only a handful of bacteria, that could pose a challenge.
Still, I love phages in general, and the idea behind PhageLab is pretty rad. The team shared their pitch deck with me, so let’s see what the company showed investors to raise its $11 million Series A round.
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Slides in this deck
The page numbering on the deck is wonky (Page 1 is labeled 1, but page 3 is labeled 2) so keep in mind that when I refer to slide numbers in this teardown, I’m referring to the page number of the PDF, not what’s on the slides themselves. The final slide is page 26 of the PDF, but it is labeled 32, so it’s clear that some slides were deleted from the deck before PhageLab shared it with me. The company says the use of funds slide has been removed, but it’s not entirely clear what else was deleted.
Still, let’s review this deck as if this were the full story and see where that takes us.
Cover slideSummary slideProblem slideProblem overview slideProblem impact slide IProblem context slideProblem summary slideProblem impact slide IIProblem impact slide III Market size slide “This is how we do it” interstitial slide Value proposition slide “What are phages” slide Why now slide Solution slide I Solution slide II Field trial results slide “Meet our team” interstitial slide Team size slide Headquarters slide Team slide Summary slide Closing slide Contact slide Appendix interstitial slide Appendix: Videos slide
Three things to love
There’s some truly fantastic storytelling in this deck.
So what about big pharma?
Startups in this space always have to worry about the big pharma companies. They can definitely outspend you, so the question is how you’re going to outsmart them.
This slide goes a long way toward answering that: The business case for developing new antibiotics is plummeting, which opens the door for PhageLab.
That makes the urgency clear . . .
I do have a thing or two to say about how the company outlines its problem statement, but slide 9 made me catch my breath. If we are 25 years away from this doomsday scenario, it’s obvious that there’s a huge opportunity for startups that can make a real impact in this space. It’s powerful storytelling.
That’s a hell of a promise of success
Bacteria are pretty nebulous, so where do you even begin? It seems to me like PhageLab asked itself: What’s a bacteria that everyone knows exists, knows where it exists, and is often in the media? Salmonella fits the bill nicely. The company has done its research and reckons it can remove salmonella altogether — a huge and obvious benefit for food supply chains.
In the rest of this teardown, we’ll take a look at three things PhageLab could have improved or done differently, along with its full pitch deck!
Three things that could be improved
This deck is very, very long. Most successful slide decks these days have 16 slides, and PhageLab could probably have shortened this deck to tell the full story in 16 to 18 slides as well.
Okay, I get it. It’s a problem.
I’m stumbling over the sheer number of problem slides. Slides 3–9 all cover various aspects of the problem, and they do so in a somewhat hyperbolic “omg this is a disaster” way:
PhageLab could have shortened its deck significantly here by reducing this part to two slides: The problem slide itself (what’s the problem?) and the problem impact slide (what happens if we don’t solve this problem). We get it, it’s a huge problem and people are going to die. It’s good storytelling, yes, but there’s no real benefit from getting dramatic about it.
Them’s some pretty buildings
Whenever I work with startups as a pitch coach, I make them defend every slide. Is it really necessary? What part of the story does this reinforce? Will an investor choose to invest because the slide is here and might they choose not to if it wasn’t? Slide 20 doesn’t pass that sniff test. Yes, you have offices in three countries, but we don’t need pictures of them. This slide is a bit of a waste.
Erm . . .
Forget what I said about the slide with the buildings. This is a waste of a slide. “Science works and we can prove it” sounds like it has to be a mistranslation or a misunderstanding of some sort. Of course science works. That’s what science does.
I want to note that PhageLab also uses “science works and we can prove it” on its website as a slogan of sorts. Unfortunately, it just isn’t a very good slogan. It could be used by literally any startup.
Some judicious pruning of this pitch deck would have gone a long way. In fact, I created an eight-slide version of this deck (just by deleting superfluous slides) that has 90% of the impact of the original.
The full pitch deck
Haje’s drastically shortened deck
In addition to these eight slides, I’d add in the Ask, Use of Funds, and Team slides and call it a day.
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